Derek Brown
Derek Brown, Ph.D., M.S.
Division of Cancer Epidemiology and Genetics (DCEG)
Entry Year

Doctoral Degree

Ph.D., Biostatistics, University of Texas Health Science Center (2019)

Master's Degree

M.S., George Washington University (2014)

Research Interests

Disease Detection; Disease Association; Biomarkers; Biostatistics

Primary Preceptor/Branch

Mitchell Machiela, Integrative Tumor Epidemiology Branch (IETB), Human Genetics Program, Division of Cancer Epidemiology & Genetics (DCEG)

Program Spotlight

Dr. Derek Brown Explores Biological Mechanisms Linking Somatic Loss of Y Chromosome to Cancer

Dr. Derek Brown
April 6, 2020

Dr. Derek Brown, a current CPFP Fellow housed in the NCI Division of Cancer Epidemiology and Genetics (DCEG), recently published an editorial titled “Why Y? Downregulation of Chromosome Y Genes Potentially Contributes to Elevated Cancer Risk.” The piece was released January 16, 2020, in the JNCI:  Journal of the National Cancer Institute.

In men, somatic loss of the Y chromosome, referred to as mosaic loss of Y (LOY), has been shown to be associated with both hematological malignancies as well as solid tumors. Although observational studies have suggested a connection between LOY and cancer, little is known about the biological mechanisms which link LOY to cancer. Within the article, Dr. Brown and his DCEG preceptor and NIH Earl Stadtman Investigator, Dr. Mitchell Machiela, discuss new findings which suggest down-regulation of chromosome Y gene expression as a possible mediator between LOY and cancer risk.

Post publication, Drs. Brown and Machiela continue to investigate possible biological mechanisms which could potentially connect mosaic LOY and elevated cancer risk.

Derek Brown, Ph.D.
Current Fellow, 2019 CPFP Cohort